Drug eruption
☆ I 2022 Stiftung Warentest-resultatene fra Tyskland var forbrukertilfredsheten med ModelDerm bare litt lavere enn med betalte telemedisinkonsultasjoner.
Drug eruption er preget av å påvirke hele kroppen.
References
Hudreaksjoner forårsaket av medisiner, kjent som medikamentutbrudd, kan noen ganger være alvorlige. Disse alvorlige reaksjonene, kalt severe cutaneous adverse drug reactions (SCARs) , anses som livstruende. De inkluderer betingelser som Stevens-Johnson syndrome (SJS) , toxic epidermal necrolysis (TEN) , acute generalized exanthematous pustulosis (AGEP) , and drug reaction with eosinophilia and systemic symptoms (DRESS) . Mens SCARs er sjeldne, opplever rundt 2 % av innlagte pasienter dem.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
En 31 år gammel kvinne oppsøkte hudavdelingen med en smertefri rød flekk på toppen av høyre fot. Hun tok én dose doksycyklin (100 mg) dagen før, etter picosekund laserbehandling for aknearr. I fjor opplevde hun et lignende problem på samme sted etter å ha tatt samme dose doksycyklin etter laserbehandling. Hun har ingen betydelig sykehistorie og ingen andre symptomer, som feber, lokalt eller i hele kroppen.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
Stevens-Johnson syndrome (SJS) og toxic epidermal necrolysis (TEN) er to former for en alvorlig hudreaksjon, forskjellig fra andre hudsykdommer som erythema multiforme major og stafylokokk-skallet hud-syndrom, samt legemiddelreaksjoner. SJS/TEN er en sjelden og alvorlig reaksjon som forårsaker utbredt hud- og slimhinneskade, ofte med systemiske symptomer. I over 80 % av tilfellene er medisiner årsaken.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Medikamentutbrudd diagnostiseres hovedsakelig fra sykehistorien og klinisk undersøkelse. En hudbiopsi, blodprøver eller immunologiske tester kan også være nyttig.
Eksempler på vanlige legemidler som forårsaker utbruddet er antibiotika og andre antimikrobielle legemidler, sulfa-medisiner, ikke-steroide antiinflammatoriske legemidler (NSAIDs), kjemoterapimidler for maligniteter, antikonvulsiva og psykotrope legemidler.
○ Diagnose og behandling
Hvis du har feber (økt kroppstemperatur), bør du søke lege så snart som mulig. Det mistenkte legemidlet bør seponeres (f.eks. antibiotika, ikke-steroide antiinflammatoriske legemidler). Før du besøker sykehus, kan orale antihistaminer som cetirizin eller loratadin hjelpe mot kløe og utslett.
#Cetirizine [Zytec]
#LevoCetirizine [Xyzal]
#Loratadine [Claritin]
Blodprøve (CBC, LFT, eosinofiltall)
Orale steroider og antihistaminer med resept fra lege